Associations of coffee drinking with systemic immune and inflammatory markers
Identifieur interne : 000818 ( Main/Exploration ); précédent : 000817; suivant : 000819Associations of coffee drinking with systemic immune and inflammatory markers
Auteurs : Erikka Loftfield [États-Unis] ; Meredith S. Shiels [États-Unis] ; Barry I. Graubard [États-Unis] ; Hormuzd A. Katki [États-Unis] ; Anil K. Chaturvedi [États-Unis] ; Britton Trabert [États-Unis] ; Ligia A. Pinto [États-Unis] ; Troy J. Kemp [États-Unis] ; Fatma M. Shebl [États-Unis] ; Susan T. Mayne [États-Unis] ; Nicolas Wentzensen [États-Unis] ; Mark P. Purdue [Canada] ; Allan Hildesheim [États-Unis] ; Rashmi Sinha [États-Unis] ; Neal D. Freedman [États-Unis]Source :
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [ 1055-9965 ] ; 2015.
Abstract
Coffee drinking has been inversely associated with mortality as well as cancers of the endometrium, colon, skin, prostate, and liver. Improved insulin sensitivity and reduced inflammation are among the hypothesized mechanisms by which coffee drinking may affect cancer risk; however, associations between coffee drinking and systemic levels of immune and inflammatory markers have not been well characterized.
We used Luminex bead-based assays to measure serum levels of 77 immune and inflammatory markers in 1,728 older non-Hispanic Whites. Usual coffee intake was self-reported using a food frequency questionnaire. We used weighted multivariable logistic regression models to examine associations between coffee and dichotomized marker levels. We conducted statistical trend tests by modeling the median value of each coffee category and applied a 20% false discovery rate criterion to P-values.
Ten of the 77 markers were nominally associated (P-value for trend<0.05) with coffee drinking. Five markers withstood correction for multiple comparisons and included aspects of the host response namely chemotaxis of monocytes/macrophages (IFNγ, CX3CL1/fractalkine, CCL4/MIP-1β), pro-inflammatory cytokines (sTNFRII) and regulators of cell growth (FGF-2). Heavy coffee drinkers had lower circulating levels of IFNγ (OR=0.35; 95% CI 0.16–0.75), CX3CL1/fractalkine (OR=0.25; 95% CI 0.10–0.64), CCL4/MIP-1β (OR=0.48; 95% CI 0.24–0.99), FGF-2 (OR=0.62; 95% CI 0.28–1.38), and sTNFRII (OR=0.34; 95% CI 0.15–0.79) than non-coffee drinkers.
Lower circulating levels of inflammatory markers among coffee drinkers may partially mediate previously observed associations of coffee with cancer and other chronic diseases.
Validation studies, ideally controlled feeding trials, are needed to confirm these associations.
Url:
DOI: 10.1158/1055-9965.EPI-15-0038-T
PubMed: 25999212
PubMed Central: 4490956
Affiliations:
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Shebl</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Yale Cancer Center, New Haven, CT</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Yale Cancer Center, New Haven</wicri:cityArea></affiliation></author><author><name sortKey="Mayne, Susan T" sort="Mayne, Susan T" uniqKey="Mayne S" first="Susan T." last="Mayne">Susan T. Mayne</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Yale Cancer Center, New Haven, CT</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Yale Cancer Center, New Haven</wicri:cityArea></affiliation></author><author><name sortKey="Wentzensen, Nicolas" sort="Wentzensen, Nicolas" uniqKey="Wentzensen N" first="Nicolas" last="Wentzensen">Nicolas Wentzensen</name><affiliation wicri:level="2"><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Purdue, Mark P" sort="Purdue, Mark P" uniqKey="Purdue M" first="Mark P." last="Purdue">Mark P. 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Shiels</name><affiliation wicri:level="2"><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Graubard, Barry I" sort="Graubard, Barry I" uniqKey="Graubard B" first="Barry I." last="Graubard">Barry I. Graubard</name><affiliation wicri:level="2"><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Katki, Hormuzd A" sort="Katki, Hormuzd A" uniqKey="Katki H" first="Hormuzd A." last="Katki">Hormuzd A. Katki</name><affiliation wicri:level="2"><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Chaturvedi, Anil K" sort="Chaturvedi, Anil K" uniqKey="Chaturvedi A" first="Anil K." last="Chaturvedi">Anil K. Chaturvedi</name><affiliation wicri:level="2"><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Trabert, Britton" sort="Trabert, Britton" uniqKey="Trabert B" first="Britton" last="Trabert">Britton Trabert</name><affiliation wicri:level="2"><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Pinto, Ligia A" sort="Pinto, Ligia A" uniqKey="Pinto L" first="Ligia A." last="Pinto">Ligia A. Pinto</name><affiliation wicri:level="2"><nlm:aff id="A3">HPV Immunology Laboratory, Leidos Biomedical Research, Inc., SAIC-Frederick/NCI-Frederick, Frederick, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>HPV Immunology Laboratory, Leidos Biomedical Research, Inc., SAIC-Frederick/NCI-Frederick, Frederick</wicri:cityArea></affiliation></author><author><name sortKey="Kemp, Troy J" sort="Kemp, Troy J" uniqKey="Kemp T" first="Troy J." last="Kemp">Troy J. Kemp</name><affiliation wicri:level="2"><nlm:aff id="A3">HPV Immunology Laboratory, Leidos Biomedical Research, Inc., SAIC-Frederick/NCI-Frederick, Frederick, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>HPV Immunology Laboratory, Leidos Biomedical Research, Inc., SAIC-Frederick/NCI-Frederick, Frederick</wicri:cityArea></affiliation></author><author><name sortKey="Shebl, Fatma M" sort="Shebl, Fatma M" uniqKey="Shebl F" first="Fatma M." last="Shebl">Fatma M. Shebl</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Yale Cancer Center, New Haven, CT</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Yale Cancer Center, New Haven</wicri:cityArea></affiliation></author><author><name sortKey="Mayne, Susan T" sort="Mayne, Susan T" uniqKey="Mayne S" first="Susan T." last="Mayne">Susan T. Mayne</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Yale Cancer Center, New Haven, CT</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Yale Cancer Center, New Haven</wicri:cityArea></affiliation></author><author><name sortKey="Wentzensen, Nicolas" sort="Wentzensen, Nicolas" uniqKey="Wentzensen N" first="Nicolas" last="Wentzensen">Nicolas Wentzensen</name><affiliation wicri:level="2"><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Purdue, Mark P" sort="Purdue, Mark P" uniqKey="Purdue M" first="Mark P." last="Purdue">Mark P. Purdue</name><affiliation wicri:level="1"><nlm:aff id="A5">Ontario Institute for Cancer Research, Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Ontario Institute for Cancer Research, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Hildesheim, Allan" sort="Hildesheim, Allan" uniqKey="Hildesheim A" first="Allan" last="Hildesheim">Allan Hildesheim</name><affiliation wicri:level="2"><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Sinha, Rashmi" sort="Sinha, Rashmi" uniqKey="Sinha R" first="Rashmi" last="Sinha">Rashmi Sinha</name><affiliation wicri:level="2"><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Freedman, Neal D" sort="Freedman, Neal D" uniqKey="Freedman N" first="Neal D." last="Freedman">Neal D. Freedman</name><affiliation wicri:level="2"><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda</wicri:cityArea></affiliation></author></analytic><series><title level="j">Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology</title><idno type="ISSN">1055-9965</idno><idno type="eISSN">1538-7755</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P2">Coffee drinking has been inversely associated with mortality as well as cancers of the endometrium, colon, skin, prostate, and liver. Improved insulin sensitivity and reduced inflammation are among the hypothesized mechanisms by which coffee drinking may affect cancer risk; however, associations between coffee drinking and systemic levels of immune and inflammatory markers have not been well characterized.</p></sec><sec id="S2"><title>Methods</title><p id="P3">We used Luminex bead-based assays to measure serum levels of 77 immune and inflammatory markers in 1,728 older non-Hispanic Whites. Usual coffee intake was self-reported using a food frequency questionnaire. We used weighted multivariable logistic regression models to examine associations between coffee and dichotomized marker levels. We conducted statistical trend tests by modeling the median value of each coffee category and applied a 20% false discovery rate criterion to P-values.</p></sec><sec id="S3"><title>Results</title><p id="P4">Ten of the 77 markers were nominally associated (P-value for trend<0.05) with coffee drinking. Five markers withstood correction for multiple comparisons and included aspects of the host response namely chemotaxis of monocytes/macrophages (IFNγ, CX3CL1/fractalkine, CCL4/MIP-1β), pro-inflammatory cytokines (sTNFRII) and regulators of cell growth (FGF-2). Heavy coffee drinkers had lower circulating levels of IFNγ (OR=0.35; 95% CI 0.16–0.75), CX3CL1/fractalkine (OR=0.25; 95% CI 0.10–0.64), CCL4/MIP-1β (OR=0.48; 95% CI 0.24–0.99), FGF-2 (OR=0.62; 95% CI 0.28–1.38), and sTNFRII (OR=0.34; 95% CI 0.15–0.79) than non-coffee drinkers.</p></sec><sec id="S4"><title>Conclusions</title><p id="P5">Lower circulating levels of inflammatory markers among coffee drinkers may partially mediate previously observed associations of coffee with cancer and other chronic diseases.</p></sec><sec id="S5"><title>Impact</title><p id="P6">Validation studies, ideally controlled feeding trials, are needed to confirm these associations.</p></sec></div></front></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Connecticut</li><li>Maryland</li></region></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Loftfield, Erikka" sort="Loftfield, Erikka" uniqKey="Loftfield E" first="Erikka" last="Loftfield">Erikka Loftfield</name></region><name sortKey="Chaturvedi, Anil K" sort="Chaturvedi, Anil K" uniqKey="Chaturvedi A" first="Anil K." last="Chaturvedi">Anil K. Chaturvedi</name><name sortKey="Freedman, Neal D" sort="Freedman, Neal D" uniqKey="Freedman N" first="Neal D." last="Freedman">Neal D. Freedman</name><name sortKey="Graubard, Barry I" sort="Graubard, Barry I" uniqKey="Graubard B" first="Barry I." last="Graubard">Barry I. Graubard</name><name sortKey="Hildesheim, Allan" sort="Hildesheim, Allan" uniqKey="Hildesheim A" first="Allan" last="Hildesheim">Allan Hildesheim</name><name sortKey="Katki, Hormuzd A" sort="Katki, Hormuzd A" uniqKey="Katki H" first="Hormuzd A." last="Katki">Hormuzd A. Katki</name><name sortKey="Kemp, Troy J" sort="Kemp, Troy J" uniqKey="Kemp T" first="Troy J." last="Kemp">Troy J. Kemp</name><name sortKey="Loftfield, Erikka" sort="Loftfield, Erikka" uniqKey="Loftfield E" first="Erikka" last="Loftfield">Erikka Loftfield</name><name sortKey="Mayne, Susan T" sort="Mayne, Susan T" uniqKey="Mayne S" first="Susan T." last="Mayne">Susan T. Mayne</name><name sortKey="Mayne, Susan T" sort="Mayne, Susan T" uniqKey="Mayne S" first="Susan T." last="Mayne">Susan T. Mayne</name><name sortKey="Pinto, Ligia A" sort="Pinto, Ligia A" uniqKey="Pinto L" first="Ligia A." last="Pinto">Ligia A. Pinto</name><name sortKey="Shebl, Fatma M" sort="Shebl, Fatma M" uniqKey="Shebl F" first="Fatma M." last="Shebl">Fatma M. Shebl</name><name sortKey="Shebl, Fatma M" sort="Shebl, Fatma M" uniqKey="Shebl F" first="Fatma M." last="Shebl">Fatma M. Shebl</name><name sortKey="Shiels, Meredith S" sort="Shiels, Meredith S" uniqKey="Shiels M" first="Meredith S." last="Shiels">Meredith S. Shiels</name><name sortKey="Sinha, Rashmi" sort="Sinha, Rashmi" uniqKey="Sinha R" first="Rashmi" last="Sinha">Rashmi Sinha</name><name sortKey="Trabert, Britton" sort="Trabert, Britton" uniqKey="Trabert B" first="Britton" last="Trabert">Britton Trabert</name><name sortKey="Wentzensen, Nicolas" sort="Wentzensen, Nicolas" uniqKey="Wentzensen N" first="Nicolas" last="Wentzensen">Nicolas Wentzensen</name></country><country name="Canada"><noRegion><name sortKey="Purdue, Mark P" sort="Purdue, Mark P" uniqKey="Purdue M" first="Mark P." last="Purdue">Mark P. Purdue</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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